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JB-95 (acetate)

JB-95 acetate, a β-hairpin macrocyclic peptide, exhibits potent antimicrobial activity against Escherichia coli. JB-95 acetate can selectively disrupt the outer membrane but not the inner membrane of E. coli[1].

Product Specifications

UNSPSC

12352209

Target

Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/jb-95-acetate.html

Purity

98.39

Solubility

H2O : ≥ 50 mg/mL

Smiles

O=C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@](C(N[C@@H](C(N[C@H](C(N[C@H]1CCCCN)=O)CC2=CNC3=CC=CC=C23)=O)CCCNC(N)=N)=O)([H])[C@@H](C)CC)=O)CCCNC(N)=N)=O)([H])[C@@H](C)CC)=O)CCCNC(N)=N)[C@@H](NC([C@@](CCC4)([H])N4C([C@](CCC5)([H])N5C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CCCNC(N)=N)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)=O)CC6=CNC7=CC=CC=C67.CC(O)=O.[x]

Molecular Formula

C92H151N35O14.xC2H4O2

Molecular Weight

1971.41 (free base)

References & Citations

[1]Urfer M, et, al. A Peptidomimetic Antibiotic Targets Outer Membrane Proteins and Disrupts Selectively the Outer Membrane in Escherichia coli. J Biol Chem. 2016 Jan 22;291 (4) :1921-1932.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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