CDK10 (E63) polyclonal antibody
Product Specifications
Background
Cdk10, also called PISSLRE, is a Cdc2-related kinase whose gene has been shown to encode two isoforms, each having a different function within the cell cycle. Although the two isoforms share nearly identical amino acid seqeunces, they differ at the C- and N- terminals. One Cdk isoform interacts with the transcription factor Ets-2, thereby modulating its transactivation activity, while the other is thought to have a role at the G2/M transition. Cdk10 mRNA has been shown to have the highest expression in lung, liver and kidney tissue, with gene upregulation implicated in cases of non-Hodgkin’s follicular lymphoma.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Cyclin-dependent kinase 10; Cell division protein kinase 10; Serine/threonine-protein kinase PISSLRE; CDK10
Swiss Prot
Q15131
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 30-84 of Human Cdk10.
Conjugation
Unconjugated
Applications
IHC
Dilution
IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 43 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Cdk10 (E63) polyclonal antibody detects endogenous levels of Cdk10 protein.
Host or Source
Rabbit
Available Sizes
Curated Selection
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