AMPK-IN-1
Product Specifications
UNSPSC Description
AMPK-IN-1 is an activator of AMPK (EC50: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way[1][2][3].
Target Antigen
AMPK
Type
Reference compound
Related Pathways
Epigenetics;PI3K/Akt/mTOR
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ampk-in-1.html
Purity
99.91
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC(OC2=NC3=CC(Cl)=C(C4=CC5=C(C=C4)C=CN5C)C=C3N2)=CC=C1C
Molecular Weight
431.87
References & Citations
[1]Ngoei KRW, et al. Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4. Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9. |[2]Cao Y, et al. Novel cyclic benzimidazole derivatives useful anti-diabetic agents. Patent. WO2010036613. |[3]Johanns M, et al. Direct and indirect activation of eukaryotic elongation factor 2 kinase by AMP-activated protein kinase. Cell Signal. 2017 Aug;36:212-221.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120904/AMPK-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120904/AMPK-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1219739-95-3
Available Sizes
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