D609

D609, an antitumoural xanthate, is a specific and competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor with a Ki of 6.4 μM. D609 is an antioxidative protector and has antiviral and anti-inflammatory activity[1][2][3].

Product Specifications

CAS Number

[83373-60-8]

UNSPSC

12352100

Hazard Statement

H302

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/D609.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic)

Smiles

S=C(OC1C2C3CCCC3C(C1)C2)S[K]

Molecular Formula

C11H15KOS2

Molecular Weight

266.46

Precautions

H302

References & Citations

[1]E Amtmann, et al. The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Exp Clin Res. 1996;22 (6) :287-94.|[2]Lu Zhang, et al. D609 inhibits progression of preexisting atheroma and promotes lesion stability in apolipoprotein e-/- mice: a role of phosphatidylcholine-specific phospholipase in atherosclerosis. Arterioscler Thromb Vasc Biol. 2010 Mar;30 (3) :411-8.|[3]Gusain A, et al. Anti-proliferative effects of tricyclodecan-9-yl-xanthogenate (D609) involve ceramide and cell cycle inhibition.Mol Neurobiol. 2012 Jun;45 (3) :455-64. Epub 2012 Mar 14.|[4]Rachele Pandolfi, et al. Role of acid sphingomyelinase and IL-6 as mediators of endotoxin-induced pulmonary vascular dysfunction. Thorax. 2017 May;72 (5) :460-471.|[5]Kalluri HS, et al. D609 inhibits the proliferation of neural progenitor cells.Neuroreport. 2010 Jul 14;21 (10) :700-3.