PERK, Akt, EGFR Antibody

GC1118 (GC-1118A) is a fully human anti-EGFR monoclonal antibody with a KD value of 0.16 nM against EGFR. It potently inhibits signal transduction triggered by both high-affinity and low-affinity EGFR ligands. GC1118 exhibits strong antiproliferative activity in both KRAS wild-type and KRAS mutant cells. It can penetrate the blood-brain barrier (BBB) and blood-tumor barrier (BTB) to reach tumor sites and demonstrates excellent antitumor effects in various mouse xenograft models. GC1118 is applicable for cancer studies, including colorectal cancer.