1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe
Product Specifications
Product Name Alternative
SC-39026; Declaben
UNSPSC Description
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-Pe (SAPE) by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/1-stearoyl-2-15-s-hpete-sn-glycero-3-pe.html
Smiles
O=C(CCC/C=C\C/C=C\C/C=C\C=C\[C@@H](OO)CCCCC)O[C@H](COC(CCCCCCCCCCCCCCCCC)=O)COP(OCCN)(O)=O
Molecular Weight
800.05
References & Citations
[1]Kagan, et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat. Chem. Biol. 13(1), 81-90 (2017).
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115701/1-Stearoyl-2-15-S-Hpete-Sn-Glycero-3-Pe-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115701/
Clinical Information
No Development Reported
CAS Number
154436-49-4
Available Sizes
Curated Selection
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