Phenazine (methylsulfate)

Phenazine methylsulfate is a free radical generator that can act as an electron transfer reactant in cell viability assays. It also has insecticidal properties. Furthermore, Phenazine methylsulfate induces oxidative DNA damage and cell apoptosis, showing antitumor activity[1][2][3].

Product Specifications

CAS Number

[299-11-6]

Product Name Alternative

5-Methylphenazinium (methylsulfate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Apoptosis; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/phenazine-methylsulfate.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

C[N+]1=C2C=CC=CC2=NC3=C1C=CC=C3.O=S(OC)([O-])=O

Molecular Formula

C14H14N2O4S

Molecular Weight

306.34

Precautions

H302, H315, H319, H335

References & Citations

[1]G E Edwards, et al. Action of phenazine methyl sulfate, inhibitors, and uncouplers on the light-induced proton transport by cells ofRhodospirillum rubrum. J Membr Biol. 1970 Dec;2 (1) :95-107.|[2]Anh B Hua, et al. Repurposing the Electron Transfer Reactant Phenazine Methosulfate (PMS) for the Apoptotic Elimination of Malignant Melanoma Cells through Induction of Lethal Oxidative and Mitochondriotoxic Stress. Cancers (Basel) . 2019 Apr 27;11 (5) :590.|[3]E Pontiki, et al. Evaluation of anti-inflammatory and antioxidant activities of copper (II) Schiff mono-base and copper (II) Schiff base coordination compounds of dien with heterocyclic aldehydes and 2-amino-5-methyl-thiazole. J Enzyme Inhib Med Chem. 2008 Dec;23 (6) :1011-7.