(±) -BI-D

(±) -BI-D is a potent ALLINI (allosteric integrase inhibitor) . (±) -BI-D binds integrase at the LEDGF/p75 binding site. (±) -BI-D inhibits HIV-Luc infection in cells (IC50: 0.16 μM in Psip1 knockout E9 mouse embryonic fibroblasts, 2.9 μM in wild-type E9 mouse embryonic fibroblasts) [1][2].

Product Specifications

CAS Number

[1416258-16-6]

UNSPSC

12352005

Target

HIV; HIV Integrase

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/__plusmn__-BI-D.html

Purity

98.06

Solubility

DMSO : ≥ 100 mg/mL

Smiles

OC(C(OC(C)(C)C)C1=C(C(C=CC=C2)=C2N=C1C)C3=CC(CCCO4)=C4C=C3)=O

Molecular Formula

C25H27NO4

Molecular Weight

405.49

References & Citations

[1]Wang H, et al. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Res. 2012 Dec;40 (22) :11518-30.|[2]Fader LD, et al. Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV. ACS Med Chem Lett. 2014 Apr 16;5 (6) :711-6.