Tenofovir alafenamide fumarate

Tenofovir alafenamide fumarate (GS-7340 fumarate) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.

Product Specifications

CAS Number

[379270-38-9]

Product Name Alternative

GS-7340 (fumarate)

UNSPSC

12352005

Hazard Statement

H315, H317, H318, H334, H335, H341, H361, H370, H413

Target

HIV; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/GS-7340-fumarate.html

Purity

99.87

Solubility

DMSO : ≥ 36 mg/mL|H2O : ≥ 25 mg/mL

Smiles

NC1=NC=NC2=C1N=CN2C[C@@H](C)OC[P@](OC3=CC=CC=C3)(N[C@@H](C)C(OC(C)C)=O)=O.O=C(O)/C=C/C(O)=O

Molecular Formula

C25H33N6O9P

Molecular Weight

592.54

Precautions

H315, H317, H318, H334, H335, H341, H361, H370, H413

References & Citations

[1]Babusis D, et al. Mechanism for effective lymphoid cell and tissue loading following oral administration of nucleotide prodrug GS-7340. Mol Pharm. 2013 Feb 4;10 (2) :459-66.|[2]Ruane PJ, et al. Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults. J Acquir Immune Defic Syndr. 2013 Aug 1;63 (4) :449-55.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

HIV-1; HIV-2

Citation 01

Univerzita Karlova v Praz. 2021 Jun.|ACS Infect Dis. 2025 Oct 30.|Antimicrob Agents Chemother. 2019 Mar 27;63 (4) . pii: e02143-18.|Antimicrob Agents Chemother. 2019 Mar 27;63 (4) :e02143-18.|J Antimicrob Chemother. 2017 Jun 1;72 (6) :1731-1740.|J Chromatogr B Analyt Technol Biomed Life Sci. 2025 Oct 1.|J Gastroenterol. 2020 Apr;55 (4) :441-452|J Med Chem. 2024 May 9;67 (9) :7470-7486.|Pharmaceuticals (Basel) . 2025 Oct 16;18 (10) :1560.|Pharmaceutics. 2021 Oct 11;13 (10) :1656.|Research Square Print. 2023 Mar 20.