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T-cell Immunoglobulin Mucin-2 (TIM-2)

TIM-2 is a type I membrane protein and is a member of the TIM protein family. TIM-2 has an immunoglobulin variable region-like domain followed by a mucin-like domain in its extracellular region.This protein family is characterized by their conserved immunoglobulin and mucin domains, as well as by their expression on activated T cells. TIM-2 is a receptor for Semaphorin 4A, which is expressed on dendritic cells and B cells. Semaphorin 4A has been shown to enhance T cell activation.

Product Specifications

Synonyms

Timd2; G9D3; Tim2; TIM-2; C78111; AA816106; AU019358; AU019662

NCBI Gene ID

171284

UniProt

Q8R183

Accession Number

NP_599010.4

Accession Number mRNA

NM_134249.5

Chromosomal Location

11 B1.1; 11

Reactivity

Anti-Mouse

Cross Reactivity

Mouse

Target Antigen

Mouse recombinant protein of TIM-2

Clone

(#5B23)

Applications

WB, IHC (P)

Purification Method

Protein A/G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Host or Source

Rat

Isotype

IgG2

Frequently Asked Questions

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