IL-4 receptor alpha, soluble
IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (γc) . The type I receptor contains, in addition to the γc, an IL-4Rα subunit, whereas the type II receptor contains the IL-13Rα. The secreted extracellular domain of IL-4Rα, called sIL-4Rα, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE.
Product Specifications
Synonyms
Soluble Interleukin-4Rα, soluble IL-4 Receptor alpha, CD124
NCBI Gene ID
3566
UniProt
P24394
Accession Number
NP_000409.1
Accession Number mRNA
NM_000418
Chromosomal Location
16p12.1-p11.2
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
CHO cells derived Recombinant Human IL-4 Receptor α
Clone
Rabbit IgG
Applications
WB, ELISA
Purification Method
Antigen-affinity purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Form
Lyophilized
Reconstitution
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Storage Conditions
Host or Source
Rabbit
Isotype
Rabbit IgG
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