7,8-Dihydroxyflavone
7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF) . Displays therapeutic efficacy toward various neurological diseases[1].
Product Specifications
CAS Number
38183-03-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Trk Receptor
Type
Natural Products
Related Pathways
Apoptosis; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/7,8-Dihydroxyflavone.html
Purity
99.90
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C=C(C2=CC=CC=C2)OC3=C(O)C(O)=CC=C13
Molecular Formula
C15H10O4
Molecular Weight
254.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang Z, et al. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2014 Feb;39 (3) :638-50.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
TrkB
Available Sizes
Frequently Asked Questions
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