LY900009
LY900009 is a potent and orally active, First-in-class inhibitor of Notch signaling via selective inhibition of the γ-secretase protein (GSI) . LY900009 inhibits Notch signalling in tumor cell lines and endothelial cells (IC50=0.005-20 nM) . LY900009 can be used for advanced cancer research[1].
Product Specifications
CAS Number
[209984-68-9]
UNSPSC
12352005
Target
Notch; γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ly900009.html
Purity
98.40
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)[C@H](O)C(N[C@@H](C)C(N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C)C1=O)=O)=O
Molecular Formula
C23H27N3O4
Molecular Weight
409.48
References & Citations
[1]Shubham Pant, et al. A first-in-human phase I study of the oral Notch inhibitor, LY900009, in patients with advanced cancer. Eur J Cancer. 2016 Mar;56:1-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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