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Lipopolysaccharides, from E. coli O55:B5

Product Specifications

UNSPSC Description

Lipopolysaccharides, from E. coli O55:B5 is an endotoxin extracted from E. coli O55:B5, consisting of an antigen-specific chain, A core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O55:B5 activates TLR-4 of immune cells. Lipopolysaccharides, from E. coli O55:B5 can induce the change of body temperature in rats with dose and serotype specificity. Lipopolysaccharides, from E. coli O55:B5 caused a heterogeneous and dose-independent increase in body temperature in rats[1][2][3][4][5].

Target Antigen

Toll-like Receptor (TLR)

Type

Biochemical Assay Reagents

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/lipopolysaccharide.html

Solubility

H2O : 5 mg/mL (ultrasonic)

Smiles

[Lipopolysaccharides, from E. coli O55:B5]

References & Citations

[1]Kabanov DS, et al. Structural analysis of lipopolysaccharides from Gram-negative bacteria. Biochemistry (Mosc). 2010 Apr;75(4):383-404.|[2]Cai KC, et al. Age and sex differences in immune response following LPS treatment in mice. Brain Behav Immun. 2016 Nov;58:327-337.|[3]Heinrichs DE, et al. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Mol Microbiol. 1998 Oct;30(2):221-32.|[4]Ying Liu, et al. Podocyte-Released Migrasomes in Urine Serve as an Indicator for Early Podocyte Injury. Kidney Dis (Basel). 2020 Nov;6(6):422-433.|[5]Gayle DA, et al. Lipopolysaccharide (LPS)-induced dopamine cell loss in culture: roles of tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide. Brain Res Dev Brain Res. 2002 Jan 31;133(1):27-35.|[6]Ren Q, Guo F, Tao S, Huang R, Ma L, Fu P. Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-κB p65 and MAPK signaling pathways in septic AKI mice. Biomed Pharmacother. 2020 Feb;122:109772.|[7]Koc F, Tekeli MY, Kanbur M, Karayigit MÖ, Liman BC. The effects of chrysin on lipopolysaccharide-induced sepsis in rats. J Food Biochem. 2020 Sep;44(9):e13359.|[8]Xiao Z, Kong B, Fang J, Qin T, Dai C, Shuai W, Huang H. Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction. Bioengineered. 2021 Dec;12(2):9367-9376.|[9]Dogan M D,et al. Effects of different serotypes of Escherichia coli lipopolysaccharides on body temperature in rats[J]. Life sciences, 2000, 67(19): 2319-2329.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-D1056/Lipopolysaccharides-from-E-coli-O55-B5-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-D1056/Lipopolysaccharides-from-E-coli-O55-B5-SDS-MedChemExpress.pdf

Clinical Information

Phase 4

Available Sizes

Curated Selection

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