RIPK1-IN-19
RIPK1-IN-19 is a selective RIPK1 inhibitor (IC50=15 nM) . RIPK1-IN-19 does not show obvious activity against RIPK2, RIPK3, and RIPK4. RIPK1-IN-19 displays potent protective activity in TNFα-induced systemic inflammatory response syndrome (SIRS) model and Imiquimod (IMQ) -induced psoriasis model. RIPK1-IN-19 can be used in research on inflammation and immune system diseases[1].
Product Specifications
CAS Number
2763831-43-0
UNSPSC
12352005
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ripk1-in-19.html
Purity
98.87
Solubility
10 mM in DMSO
Smiles
C[C@@H](C1=CC=CC(F)=C1)NC(C2=CN(C3=C2C=C(C=C3)C4=CC5=NC(NC(C6CC6)=O)=NN5C=C4)C)=O
Molecular Formula
C28H25FN6O2
Molecular Weight
496.54
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1
Available Sizes
Frequently Asked Questions
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