Recombinant Glypican-3 Monoclonal Antibody

Glypican 3 belongs to Glypicans (GPCs), a family of glycosylphosphatidylinositol (GPI) -anchored heparan sulphate proteoglycans (HSPGs) that may play a role in the control of cell division and growth regulation. In mammals, there are six GPCs (GPC1 to GPC6), all of which have a similar core-protein size of approx. 60 kDa and the clustering of glycosaminoglycan attachment site near the C-terminus. They are tethered to the cell surface by GPI linkages, which can be cleaved by endogenous phospholipases, thus releasing the protein. Glypican 3 (GPC3) is highly expressed in many tissues during development and plays an important role in the regulation of embryonic growth. Loss-of-function mutations of GPC3 result in the Simpson-Golabi-Behmel overgrowth syndrome (SGBS), and Gpc-3 null mice display developmental overgrowth. In hepatocellular carcinoma (HCC), the overexpression of glypican 3 has been demonstrated to be a reliable diagnostic indicator.

MXR; GPC; UNQ; PRO; CDw; ADAM; Protein FOAP; Secreted glypican; Glypican proteoglycan; Sialic acid-binding Ig-like lectin; C20orf; OCI; GPC3; DGSX; GTR2-2; MXR7; OCI-5; SDYS; SGB; SGBS; SGBS1; glypican-3; CDw329; Glypican 3; Glypican proteoglycan 3; Glypican-3 [Precursor]; GTR2 2; Heparan sulphate proteoglycan; Intestinal protein OCI 5; Intestinal protein OCI-5; OCI 5; Protein FOAP-9; Secreted glypican-3; Sialic acid-binding Ig-like lectin 9; SIGLEC9; Siglec-9; ADAM33; C20orf153; UNQ873; PRO1891; OCI5