(S, R, S) -AHPC-Me-C6-NH2
(S, R, S) -AHPC-Me-C6-NH2 can be used for the synthesis of PROTAC[1]. (S, R, S) -AHPC-Me-C6-NH2 (Compound SI-9) contains VHL ligand 2 (HY-112078) [2].
Product Specifications
CAS Number
[2411422-49-4]
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/s-r-s-ahpc-me-c6-nh2.html
Purity
99.81
Solubility
DMSO : ≥ 100 mg/mL
Smiles
NCCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O
Molecular Formula
C30H45N5O4S
Molecular Weight
571.77
References & Citations
[1]Haibing Zhou, et al. Oseltamivir PROTAC compound, preparation method thereof and application thereof in anti-influenza virus drugs. Patent CN112592331A.|[2]Bondeson DP, et al. Systematic profiling of conditional degron tag technologies for target validation studies. Nat Commun. 2022 Sep 20;13 (1) :5495.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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NALP4 (NACHT-, LRR-and PYD-containing Protein 4, NACHT Leucine Rich Repeat and PYD Containing 4, CLR19.5, FLJ32126, Nucleotide Binding Oligomerization Domain Leucine Rich Repeat and Pyrin Domain Containing 4, NLR Family Pyrin Domain Containing 4, NLRP4, PAAD and NACHT Containing Protein 2, PAN2, PYRIN Containing APAF1-like Protein 4, PYPAF4, Ribonuclease Inhibitor 2, RNH2)
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