Pomalidomide-C12-NH2 (hydrochloride)
Pomalidomide-C12-NH2 hydrochloride is the E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1 (HY-139186) . PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C degrader[1].
Product Specifications
CAS Number
[2862774-02-3]
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pomalidomide-c12-nh2-hydrochloride.html
Purity
97.09
Solubility
10 mM in DMSO
Smiles
NCCCCCCCCCCCCNC1=C(C(N(C2CCC(NC2=O)=O)C3=O)=O)C3=CC=C1.Cl
Molecular Formula
C25H37ClN4O4
Molecular Weight
493.04
References & Citations
[1]Zeng M, et, al. Exploring Targeted Degradation Strategy for Oncogenic KRAS G12C. Cell Chem Biol. 2020 Jan 16;27 (1) :19-31.e6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Rabbit Monoclonal PPIL1 Antibody (003) [Alexa Fluor 488]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
NBP2-90270AF488 0.1 mL
Rabbit Monoclonal PPIL1 Antibody (003) [Alexa Fluor 488]
Sign In for Pricing
View Details 
GTR15156365 1 Vial
Lentiviral mouse Hscb shRNA (UAS) - Lentiviral mouse Hscb shRNA (UAS) (25)
Sign In for Pricing
View Details K1065406 1.0 µg DNA
IGLV3-4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
Sign In for Pricing
View Details 
K6078507 1.0 µg DNA
Spg20 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)
Sign In for Pricing
View Details