CTNNA1 Recombinant Protein
Product Specifications
CAS Number
9000-83-3
Gene Name
Catenin alpha 1
Gene Aliases
Alpha E-catenin; alpha-E-catenin; Cadherin-associated protein; CAP102; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin alpha-1; epididymis secretory sperm binding protein; MDPT2; renal carcinoma antigen NY-REN-13.
Gene ID
1495
Accession Number
NP_001277236.1
Reactivity
Homo sapiens|Human
Target
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Conjugation
Unconjugated
Type
Protein
Source
E.coli
Applications
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
200 ug/mL (prior to lyoph)
Format
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Reconstitution
2°C to 8°C|-80°C
Molecular Weight
32kDa
Protein Length
Recombinant
NCBI Gene Symbol
CTNNA1
Host or Source
E.coli
Protein Name
Catenin alpha-1
Gene Name URL
CTNNA1
Nucleotide Accession Number
NM_001290307.2
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1490027-01 0.05 mg
Rabbit anti-human Deoxynucleotidyltransferase terminal-interacting protein 1 polyclonal Antibody, HRP conjugated
Ask
View Details MBS1490027-02 0.1 mg
Rabbit anti-human Deoxynucleotidyltransferase terminal-interacting protein 1 polyclonal Antibody, HRP conjugated
Ask
View Details MBS1490027-03 5x 0.1 mg
Rabbit anti-human Deoxynucleotidyltransferase terminal-interacting protein 1 polyclonal Antibody, HRP conjugated
Ask
View Details bs-10903R-PerCP-Cy5.5 100 µL
Myosin heavy chain 2 Polyclonal Antibody, PerCP-Cy5.5 Conjugated
Ask
View Details