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Resiniferatoxin

Resiniferatoxin ((+) -Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period[1][2].

Product Specifications

CAS Number

57444-62-9

Product Name Alternative

(+) -Resiniferatoxin

UNSPSC

12352005

Hazard Statement

H301, H314, H315, H319, H335

Target

TRP Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/resiniferatoxin.html

Purity

99.77

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@H]1[C@]23[C@](C=C(C[C@]4([C@@]3([H])C=C(C4=O)C)O)COC(CC5=CC(OC)=C(C=C5)O)=O)([H])[C@]6([H])[C@](C1)(O[C@](O2)(O6)CC7=CC=CC=C7)C(C)=C

Molecular Formula

C37H40O9

Molecular Weight

628.71

Precautions

H301, H314, H315, H319, H335

References & Citations

[1]Brown DC. Resiniferatoxin: The Evolution of the "Molecular Scalpel" for Chronic Pain Relief. Pharmaceuticals (Basel) . 2016;9 (3) :47. Published 2016 Aug 11.|[2]Wu Y, et al. Resiniferatoxin reduces ventricular arrhythmias in heart failure via selectively blunting cardiac sympathetic afferent projection into spinal cord in rats. Eur J Pharmacol. 2020;867:172836.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

Phase 3

Available Sizes

Frequently Asked Questions

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