Humulone

Humulone (α-Lupulic acid), a prenylated phloroglucinol derivative, is a potent cyclooxygenase-2 (COX-2) inhibitor. Humulone acts as a positive modulator of GABAA receptor at low micromolar concentrations. Humulone is an inhibitor of bone resorption. Humulone possesses antioxidant, anti-angiogenic and apoptosis-inducing properties[1][2][3].

Product Specifications

CAS Number

[26472-41-3]

Product Name Alternative

α-Lupulic acid

UNSPSC

12352211

Target

Apoptosis; COX; GABA Receptor

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/humulone.html

Purity

99.46

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C/C(C)=C/C[C@@]1(C(C(C(CC(C)C)=O)=C(O)C(C/C=C(C)\C)=C1O)=O)O

Molecular Formula

C21H30O5

Molecular Weight

362.46

References & Citations

[1]K Yamamoto, et al. Suppression of cyclooxygenase-2 gene transcription by humulon of beer hop extract studied with reference to glucocorticoid. FEBS Lett. 2000 Jan 14;465 (2-3) :103-6.|[2]Ali Y Benkherouf, et al. Humulone Modulation of GABA A Receptors and Its Role in Hops Sleep-Promoting Activity. Front Neurosci. 2020 Oct 14;14:594708.|[3]Jung-Chul Lee, et al. Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets. Carcinogenesis. 2007 Jul;28 (7) :1491-8.