CD177 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
CD177 molecule
Gene Aliases
CD177 antigen; cell surface receptor; HNA-2a; HNA2A; human neutrophil alloantigen 2a; NB1; NB1 glycoprotein; NB1 GP; polycythemia rubra vera protein 1; PRV1; PRV-1.
Gene ID
57126
Accession Number
NP_065139.2
Reactivity
Human|Non-human Primate
Immunogen
Human granulocytes
Target
In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407) . In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980) . Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308) . However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681) . Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208) . By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369) .
Clonality
Monoclonal
Clone
MEM-166
Type
Monoclonal Antibody
Applications
Flow cytometry|Immunoprecipitation|Western blot
Purification
Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Buffer
Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Reconstitution
2°C to 8°C
Fragment
IgG1
Specificity
HLDA VI; WS Code M M17 HLDA VI; WS Code BP 309//
NCBI Gene Symbol
CD177
Host or Source
Mouse
Protein Name
CD177 antigen
Gene Name URL
CD177
Nucleotide Accession Number
NM_020406.3
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