NR1H2 Antibody
Product Specifications
CAS Number
9007-83-4
Gene Name
Nuclear receptor subfamily 1, group H, member 2
Gene Aliases
AI194859; liver X receptor beta; LX; LXR; LXR beta; LXRB; LXRbeta; LXRBSV; NER1; Nuclear receptor subfamily 1 group H member 2; OR-1; oxysterols receptor LXR-beta; retinoid X receptor-interacting protein No.15; RI; RIP15; Ubiquitously-expressed nuclear receptor; ubiquitously-expressed nuclear receptor 2; Un; Unr; Unr2; UR.
Gene ID
22260
Accession Number
NP_001272446.1
Reactivity
Human|Mouse|Porcine|Rat
Immunogen
Recombinant LXRb (Met1~Glu446) expressed in E.coli
Target
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281) . Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4) (PubMed:18055760, PubMed:19520913, PubMed:20427281) . Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8 (PubMed:18055760, PubMed:19520913, PubMed:20427281) . Interplays functionally with RORA for the regulation of genes involved in liver metabolism (PubMed:18055760, PubMed:19520913, PubMed:20427281) . Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (By similarity) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
Immunocytochemistry|Immunohistochemistry|Immunoprecipitation|Western blot
Purification
Affinity Purified; Protein A Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.47 mg/ml
Format
Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution
2°C to 8°C|-20°C
Molecular Weight
50 kDa
Fragment
IgG
Specificity
The antibody is a rabbit polyclonal antibody raised against LXRb. It has been selected for its ability to recognize LXRb in immunohistochemical staining and western blotting.
NCBI Gene Symbol
Nr1h2
Host or Source
Rabbit
Protein Name
Oxysterols receptor LXR-beta
Gene Name URL
Nr1h2
Nucleotide Accession Number
NM_001285517
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