Recombinant human OAZ1 protein
Ornithine decarboxylase antizyme 1, also known as OAZ1, belongs to the ODC antizyme family. It expression is auto-regulated by polyamine-enhanced translational frameshifting. OAZ1 negatively regulates polyamine synthesis by enhancing the negative feedback loop controlling ornithine decarboxylase (ODC) activity. The OAZ1 encoded by this gene inhibits ornithine decarboxylase and accelerates its degradation. Recombinant human OAZ1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Ornithine decarboxylase antizyme 1, AZI, OAZ
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
27.8 kDa (251aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Zhang M., et al. (2003) EMBO J. 22: 1488-1496; ; Aoto H., et al. (1997) Genomics. 40: 138-141.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol,1mM DTT
Scientific Category
Metabolism
NCBI Accession Number
NP_004143.1
Uniprot Accession Number
P54368
Species
Human
AA Sequence
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