Flucytosine

Flucytosine (5-Fluorocytosine) is an antifungal compound with oral activity. Flucytosine is a widely used cytotoxic drug that, after further metabolism, produces fluorinated ribonucleotides and deoxyribonucleotides, inhibits DNA and protein synthesis, and has multiple effects such as inhibiting candida and candida neoplasm infection and producies cytotoxicity to cancer cells[1][2][3].

Product Specifications

CAS Number

[2022-85-7]

Product Name Alternative

5-Fluorocytosine; NSC 103805; Ro 2-9915

UNSPSC

12352005

Hazard Statement

H361

Target

Antibiotic; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Flucytosine.html

Purity

99.99

Solubility

DMSO : 16.67 mg/mL (ultrasonic) |H2O : 6.67 mg/mL (ultrasonic)

Smiles

O=C1NC=C(F)C(N)=N1

Molecular Formula

C4H4FN3O

Molecular Weight

129.09

Precautions

H361

References & Citations

[1]Vermes A, et al. Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions. J Antimicrob Chemother. 2000 Aug;46 (2) :171-9.|[2]You MH, et al. Cytosine deaminase-producing human mesenchymal stem cells mediate an antitumor effect in a mouse xenograft model. J Gastroenterol Hepatol. 2009 Aug;24 (8) :1393-400.|[3]Iovannitti C, et al. Itraconazole and flucytosine+itraconazole combination in the treatment of experimental cryptococcosis in hamsters. Mycoses. 1995 Nov-Dec;38 (11-12) :449-52.