CU-CPT-8m
CU-CPT-8m is a specific TLR8 antagonist, with an IC50 of 67 nM.
Product Specifications
CAS Number
[125079-83-6]
Product Name Alternative
TLR8-specific antagonist
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/CU-CPT-8m.html
Purity
99.98
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C2N=CC=C(C3=CC=CC(C)=C3)N2N=C1)N
Molecular Formula
C14H12N4O
Molecular Weight
252.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang S, et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat Chem Biol. 2018 Jan;14 (1) :58-64.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR8
Available Sizes
Curated Selection
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