R 892

Potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively) . Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo.

C(=O)([C@H]1N(C([C@@H](NC([C@H](CCCCN)NC(C)=O)=O)CCCNC(=N)N)=O)CCC1)N2[C@H](C(NCC(N([C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@H](CC4=CC5=C(C=C4)C=CC=C5)C(N[C@@H]([C@H](CC)C)C(O)=O)=O)=O)CO)=O)C)=O)=O)CCC2