Naxifylline

Naxifylline (BG9719; CVT-124) is a potent and selective A1-adenosine antagonist with Ki values of 0.67 and 0.45 nM for rat and cloned human A1-receptors, respectively. Naxifylline is a potassium-sparing diuretic for the study of edema associated with congestive heart failure[1].

Product Specifications

CAS Number

[166374-49-8]

Product Name Alternative

BG9719; CVT-124

UNSPSC

12352005

Target

Adenosine Receptor

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

CCCN1C2=C(C(N(C1=O)CCC)=O)NC([C@@H]3[C@@]4([H])[C@@]5([H])[C@]([C@](C3)([H])C4)([H])O5)=N2

Molecular Formula

C18H24N4O3

Molecular Weight

344.41

References & Citations

[1]Pfister JR, et al. Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2- (5,6-epoxynorbonyl) ]-xanthine. J Med Chem. 1997 Jun 6;40 (12) :1773-8.