AUNP-12 acetate

Product Specifications

Target

PD-1/PD-L1

Related Pathways

Immunology/Inflammation, Cell Cycle/Checkpoint, Apoptosis

Purity

0.9507

Bioactivity

AUNP-12 acetate is a polypeptide inhibitor of PD-1 that is equivalent to PD-1 and PD-2 in inhibiting lymphocyte proliferation and effector fuction, in addition to immune activation and antitumor activity.

Smiles

O=C([C@@](NC([C@](NC([C@@](NC([C@@](NC([C@@](NC([C@@](NN)(CCC(O)=O)[H])=O)(CCCCN)[H])=O)([C@@](CC)(C)[H])[H])=O)(CCC(N)=O)[H])=O)(C)[H])=O)(CCCCN)[H])N1[C@@](CCC1)(C(N[C@@](C(C([C@@](NC([C@@](NC([C@@](NC([C@@](NC([C@@](NC([C@@](NC(C(CCCCNN[C@@](CC2=CC=CC=C2)(C(N([H])[C@](C(N[C@@](C(CC(O)=O)([H])[H])(C(N[C@](C(N[C@@]([C@@](O)(C)[H])(C(N[C@@](CC(N)=O)(C(N[C@@](CO)(C([H])=O)[H])=O)[H])=O)[H])=O)(CO)[H])=O)[H])=O)(CO)[H])=O)[H])NC([C@@](N([H])C([C@@](NC([C@@](NC([C@@](NC([C@@](NC([C@@](NC([C@@](N)(CO)[H])=O)(CC(N)=O)[H])=O)([C@@](O)(C)[H])[H])=O)(CO)[H])=O)(CCC(O)=O)[H])=O)(CO)[H])=O)(CC3=CC=CC=C3)[H])=O)=O)(CC4=CC=CC=C4)[H])=O)(CCCNC(N)=N)[H])=O)(C(C)(C)[H])[H])=O)([C@@](O)(C)[H])[H])=O)(CCC(N)=O)[H])=O)(CC(C)C)[H])=O)=O)(C)[H])=O)[H].CC(O)=O