Recombinant CDK4 Monoclonal Antibody

CDK4 (cyclin dependent kinase 4) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a) . This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb) . Mutations in this gene as well as in its related proteins including D-type cyclins, p16 (INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Crk; MGC; Cell division kinase; cyclin-dependent kinase; Cyclin dependent kinase; Cell division protein kinase; Melanoma cutaneous malignant; PSK-J; PSK J; p34 cdk; CMM; CDK; CDK4; CMM3; PSK-J3; cyclin-dependent kinase 4; Cdk 4; CDK4 protein; Cell division kinase 4; Cell division protein kinase 4; CMM 3; Crk3; Cyclin dependent kinase 4; Melanoma cutaneous malignant 3; MGC14458; p34 cdk4; PSK J3; CMM3; cyclin-dependent kinase 4; PSK-J3