NecroX-7
Product Specifications
CAS Number
1120332-55-9
Target
TNF, NADPH-oxidase, Reactive Oxygen Species, TLR, Interleukin, ROS
Related Pathways
Metabolism, Immunology/Inflammation, NF-κB, Apoptosis
Purity
0.9822
Bioactivity
NecroX-7 (LC-280126) is a potent free radical scavenger and HMGB1 (high-mobility group box 1) inhibitor. It serves as an antidote to acetaminophen toxicity and exerts a protective effect by preventing HMGB1 release in ischemia/reperfusion injury. Additionally, NecroX-7 inhibits HMGB1-induced release of TNF and IL-6 and the expression of TLR-4 and receptor for advanced glycation end products. This compound may be used for graft-versus-host disease (GVHD) research [1].
Smiles
N(C1=C2C(C=C(N2)C3=CC=CC=C3)=CC(CN4CCS(=O)(=O)CC4)=C1)C5CCOCC5
Molecular Formula
C24H29N3O3S
Molecular Weight
439.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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