PD146176
Product Specifications
CAS Number
4079-26-9
Target
Ferroptosis, Lipoxygenase, Autophagy
Related Pathways
Apoptosis, Metabolism, Autophagy
Purity
0.9977
Bioactivity
PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO), it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
Smiles
C1Sc2ccccc2-c2[nH]c3ccccc3c12
Molecular Formula
C15H11NS
Molecular Weight
237.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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