Necrosulfonamide
Product Specifications
CAS Number
1360614-48-7
Target
PI4K, PI3K, MLK
Related Pathways
PI3K/Akt/mTOR signaling, MAPK
Purity
0.9949
Bioactivity
Necrosulfonamide ((E) -Necrosulfonamide) is a necroptosis inhibitor that targets MLKL and is selective. Necrosulfonamide prevents the MLKL-RIP1-RIP3 necrosomal complex from interacting with its downstream effectors.
Smiles
COc1nccnc1NS(=O)(=O)c1ccc(NC(=O)\C=C\c2ccc(s2)[N+]([O-])=O)cc1
Molecular Formula
C18H15N5O6S2
Molecular Weight
461.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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