AMG-548 dihydrochloride
Product Specifications
Target
Others, Casein Kinase, p38 MAPK
Related Pathways
Others, Stem Cells, Metabolism, MAPK
Bioactivity
AMG-548 dihydrochloride is a selective, orally active p38α inhibitor with a Ki value of 0.5 nM, a slight selectivity for p38β (Ki=36 nM) and >1000-fold selectivity for p38γ and p38δ. AMG-548 dihydrochloride exhibits inhibition of whole blood LPS-stimulated TNFα with an IC50 value of 3 nM. AMG-548 dihydrochloride directly inhibited casein kinase 1 isoforms δ and ε, and inhibited Wnt signaling.
Molecular Formula
C29H29Cl2N5O
Molecular Weight
534.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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