20S Proteasome activator 1
Product Specifications
CAS Number
2761578-18-9
Target
Proteasome
Related Pathways
Proteases/Proteasome, Ubiquitination
Purity
0.9982
Bioactivity
20S Proteasome activator 1 is a 20S proteasome activator with IC50 values of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites, and 1.8 μM for caspase sites. It prevents the accumulation of pathogenic alpha-synuclein (A53T) mutants through translation in the cellular system, thereby reducing the probability of disease occurrence. 20S Proteasome activator 1 can be used to study neurodegenerative diseases.
Smiles
C(CC(N(C1=CC=C(F)C=C1)C2=CC=C(F)C=C2)=O)N3C=4C(SC=5C3=CC=CC5)=CC=C(Cl)C4
Molecular Formula
C27H19ClF2N2OS
Molecular Weight
492.97
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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