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Simmiparib

Product Specifications

CAS Number

1551355-46-4

Target

Apoptosis, PARP

Related Pathways

Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair

Purity

0.9951

Bioactivity

Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR) -deficient cells, thereby contributing to apoptosis.Simmiparib has been used for study Parkinson's disease, Alzheimer's disease, breast cancer, and melanoma.

Smiles

CC1CN(Cc2nnc(n12)C(F)(F)F)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F

Molecular Formula

C23H18F4N6O2

Molecular Weight

486.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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