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KRAS inhibitor-16

Product Specifications

Target

Others|||Kras|||Ras

Related Pathways

GPCR/G Protein|||Others|||MAPK

Bioactivity

KRAS inhibitor-16 (compound 3-11) is a potent inhibitor of KRAS G12C (IC50: 0.457 ?M) and exhibits p-ERK inhibition in MIA PaCA-2 and A549 cells with IC50s of 3.06 and 11.1 ?M, respectively. KRAS inhibitor-16 has potential for study in pancreatic, colorectal, and lung cancers.

Smiles

FC=1C=2C(=C(SN2)N3CCN(C(C=C)=O)CC3)C=C(Cl)C1C4=C(Cl)C=CC(O)=C4

Molecular Formula

C20H16Cl2FN3O2S

Molecular Weight

452.33

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Product Datasheet

https://www.targetmol.com/attachment/DataSheet/7AEF49B1-79A4-4C9B-A016-427D759CCD18/T62752

CAS Number

2230873-67-1

Available Sizes

Curated Selection

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