Lysophosphatidic Acid, Sodium Salt
Autophagy inhibitor
Product Specifications
Background
Oleoyl-lysophosphatidic acid is an endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. It has been shown to induce cellular functions such as cell proliferation and migration, and ICAM-1, IL-8 and MCP-1 expression. Lysophosphatidic acid has also been observed to inhibit autophagy in cells under starvation conditions by inhibiting autophagosome formation.
CAS Number
22556-62-3
Product Name Alternative
Oleoyl-lysophosphatidic acid sodium salt
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Autophagy
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.025
Format
White powder.
Solubility
Soluble in DMSO (1 mg/ml) and warm water (10 mg/ml).
Molecular Formula
C21H40O7P*Na
Molecular Weight
458.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. van Corven E.J., et al. (1992) Biochem J. 281(Pt 1): 163-9. 2. Chang C.L., et al. (2007) Autophagy. 3(3): 268-70.
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