Pan-HER-IN-2
Product Specifications
CAS Number
1639040-95-1
Target
Others, Apoptosis, EGFR
Related Pathways
Others, JAK/STAT signaling, Apoptosis, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
Pan-HER-IN-2 (Compound C6) is an orally active, reversible, broad-spectrum HER inhibitor that targets EGFR (IC50: 0.72 nM), HER4 (IC50: 2.0 nM), EGFRT790M (IC50: 8.2 nM), and L858R (IC50: 75.1 nM) . pan-HER-IN-2 induces apoptosis and possesses anti-tumor effects.
Smiles
N(C=1C2=C(C=CC(NC(CCCl)=O)=C2)N=CN1)C=3C=C4C(=CC3)NC=C4Br
Molecular Formula
C19H15BrClN5O
Molecular Weight
444.71
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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