Gambogic Acid
Product Specifications
CAS Number
2752-65-0
Target
Bcl-2 Family, Autophagy
Related Pathways
Autophagy, Apoptosis
Purity
0.9867
Bioactivity
Gambogic Acid (Guttic Acid) (EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 uM, respectively.
Smiles
CC(C)=CCCC1(C)OC2=C(CC=C(C)C)C3=C(C(O)=C2C=C1)C(=O)C1=CC2CC4C(C)(C)OC(C\C=C(/C)C(O)=O)(C2=O)C14O3
Molecular Formula
C38H44O8
Molecular Weight
628.75
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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