Topoisomerase II inhibitor 3
Selected Variant
T61283-01
Size: 25 mg
Product Specifications
CAS Number
99140-25-7
Target
Apoptosis, Others, Topoisomerase
Related Pathways
Others, DNA Damage/DNA Repair, Apoptosis
Bioactivity
Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative acting as a Type II DNA topoisomerase (topo II) inhibitor. It specifically targets topo IIα/β subtypes, with IC50 values of 0.17 μM for topo IIα and 0.23 μM for topo IIβ, causing significant DNA damage and inducing apoptosis by triggering the loss of mitochondrial membrane potential [1].
Smiles
N(=O)(=O)C1=C2C(=C(NCCCN(C)C)C=C1)C(=O)C=3C(N2)=CC=C(O)C3
Molecular Formula
C18H20N4O4
Molecular Weight
356.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Price
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