MS67

Product Specifications

CAS Number

2407452-77-9

Target

PROTACs|||Histone Methyltransferase

Related Pathways

PROTAC|||Chromatin/Epigenetic

Bioactivity

MS67 is a potent and selective degrader of WD40 repeat domain protein 5 (WDR5) with a dissociation constant (Kd) of 63 nM, exhibiting no activity against protein methyltransferases, kinases, G-protein-coupled receptors (GPCRs), ion channels, and transporters, and notably demonstrating significant anticancer properties.

Smiles

C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CNC(=O)c1ccc(F)c(c1)-c1ccc(N2C[C@H](C)N(C)[C@H](C)C2)c(NC(=O)c2c[nH]c(=O)cc2C(F)(F)F)c1)C(C)(C)C)c1ccc(cc1)-c1scnc1C