K-80003

K-80003 is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth.

Product Specifications

CAS Number

[1292821-90-9]

Product Name Alternative

TX-803

UNSPSC

12352005

Target

Akt

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/K-80003.html

Concentration

10mM

Purity

99.16

Solubility

DMSO : 30 mg/mL (ultrasonic)

Smiles

CC1=C(C2=CC(F)=CC=C2/C1=C(C3=CC=C(C=C3)C(C)C)/[H])CC(O)=O

Molecular Formula

C22H21FO2

Molecular Weight

336.40

References & Citations

[1]Zhou H, et al. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell. 2010 Jun 15;17 (6) :560-73.|[2]Chen L, et al. Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα. Nat Commun. 2017 Jul 17;8:16066.