MI-3454
Product Specifications
CAS Number
2134169-43-8
Target
Histone Methyltransferase|||Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Purity
0.9968
Bioactivity
MI-3454 is an orally active, selective and potent inhibitor of Menin-MLL1 interaction that inhibits the proliferation and induces differentiation of acute leukemia cells with MLL1 translocation or NPM1 mutation.MI-3454 induces complete remission or regression of leukemia in a mouse model of leukemia with MLL1 rearrangement or NPM1 mutation through the down-regulation of key genes involved in leukemogenesis. complete remission or remission.
Smiles
CNc1nc(NC2CCN(Cc3ccc4n(CC56CC(C5)(C6)NC=O)c(cc4c3C)C#N)CC2)c2cc(CC(F)(F)F)sc2n1
Molecular Formula
C32H35F3N8OS
Molecular Weight
636.73
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Curated Selection
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