MC-SN38
Product Specifications
CAS Number
1473403-87-0
Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
MC-SN38 is a drug-linker conjugate that pairs the potent microtubule-disrupting agent SN38 with a non-cleavable MC linker, designed for use in antibody drug conjugates (ADCs) . SN38, the active metabolite of the Topoisomerase I inhibitor Irinotecan, works by inhibiting DNA synthesis and inducing DNA single-strand breaks.
Smiles
CCc1c2Cn3c(cc4c(COC(=O)[C@@]4(CC)OC(=O)CCCCCN4C(=O)C=CC4=O)c3=O)-c2nc2ccc(O)cc12
Molecular Formula
C32H31N3O8
Molecular Weight
585.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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