BM-1197
Product Specifications
CAS Number
1391107-89-3
Target
Others, Bcl-2 Family
Related Pathways
Others, Apoptosis
Bioactivity
BM-1197, a highly potent and specific dual inhibitor of Bcl-2 and Bcl-xL, effectively targets these proteins with IC50 values of 3.5 nM and 5.2 nM for Bcl-2 and Bcl-xL, respectively. This compound demonstrates notable antitumor activity in both in vitro and in vivo settings.
Smiles
CC(C)n1c(C)c(c(c1-c1ccc(Cl)cc1)-c1cc(F)cc(c1)N1CCN(CC1)c1ccc(NS(=O)(=O)c2ccc(N[C@H](CCN3CCC(O)CC3)CSc3ccccc3)c(c2)S(=O)(=O)C(F)(F)F)cc1)S(C)(=O)=O
Molecular Formula
C53H59ClF4N6O7S4
Molecular Weight
1131.77
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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