PF-04577806
Product Specifications
CAS Number
1072100-81-2
Target
Others, Phosphatase, PKC
Related Pathways
Others, Cytoskeletal Signaling, Metabolism, Chromatin/Epigenetic
Bioactivity
PF-04577806 is a potent, selective, and ATP-competitive inhibitor of protein kinase C (PKC), showing significant inhibitory activity against various PKC isoforms, including PKCα (IC50=2.4 nM), PKCβI (IC50=8.1 nM), PKCβII (IC50=6.9 nM), PKCγ (IC50=45.9 nM), and PKCθ (IC50=29.5 nM) . Additionally, it can reverse retinal vascular leakage in diabetic rats.
Smiles
C[C@@H]1CN([C@@H](C)CN1CC1CCOCC1)C(=O)N1Cc2c(NC(=O)c3ccccn3)n[nH]c2C1(C)C
Molecular Formula
C26H37N7O3
Molecular Weight
495.628
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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