N-Descyclopropanecarbaldehyde Olaparib
Product Specifications
CAS Number
763111-47-3
Target
E3 Ligase Ligand-Linker Conjugate|||PARP|||Ligands for Target Protein for PROTAC|||Others
Related Pathways
Chromatin/Epigenetic|||Others|||DNA Damage/DNA Repair|||PROTAC
Bioactivity
N-Descyclopropanecarbaldehyde Olaparib, an Olaparib analogue, incorporates a DOTA moiety. It acts as a CRBN-based ligand for the formation of novel dual EGFR and PARP PROTAC, DP-C-4[1]. N-Descyclopropanecarbaldehyde Olaparib is suitable for radiolabeling with F-18 or a fluorophore to visualize tumors using positron emission tomography (PET) or optical imaging[2].
Smiles
Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCNCC1
Molecular Formula
C20H19FN4O2
Molecular Weight
366.39
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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