Ensaculin HCl
Product Specifications
CAS Number
209969-60-8
Target
Others|||iGluR
Related Pathways
Neuroscience|||Membrane transporter/Ion channel|||Others
Bioactivity
Ensaculin is a NMDA antagonist and a 5HT1A agonist potentially for the treatment of Alzheimer's disease (AD) . Ensaculin showed memory-enhancing effects in paradigms of passive and conditioned avoidance in both normal and artificially amnesic rodents. It exhibited neuroprotective activities in an NMDA toxicity model and neurotrophic effects in primary cultured rat brain cells. In receptor-binding studies, ensaculin was found to have high affinities to serotonergic 5-HT (1A) and 5-HT (7) receptors, adrenergic alpha (1), and dopaminergic D (2) and D (3) receptors.
Smiles
Cl.O=C1OC=2C=C(OC)C(OCCCN3CCN(C=4C=CC=CC4OC)CC3)=CC2C(=C1C)C
Molecular Formula
C26H33ClN2O5
Molecular Weight
489
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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