Alpelisib
Product Specifications
CAS Number
1217486-61-7
Target
PI3K
Related Pathways
PI3K/Akt/mTOR signaling
Purity
0.9973
Bioactivity
Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity, inhibiting PI3Kβ/γ/δ with low activity (IC50=250/290/1200 nM) . Alpelisib demonstrates antitumor activity and specifically targets PIK3CA mutant tumors.
Smiles
Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(c1)C(C)(C)C(F)(F)F
Molecular Formula
C19H22F3N5O2S
Molecular Weight
441.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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